Gemma DB
A data management and genetic analysis platform for internal use at the University Hospital Freiburg.
Experimental work
Decoding nucleotide sensing and immune regulation
We investigate how genetic factors determining sensing of nucleotides and nucleic acids regulate the human immune response. Our recent work identified ADA2 as a lysosomal DNA-binding protein that efficiently deaminates deoxyadenosine residues to deoxyinosine, supporting a new model in which DNA editing influences TLR9-mediated immune detection.
Key finding 01
ADA2 binds DNA in lysosomes
Evidence indicates ADA2 is a lysosomal protein with direct DNA-binding activity, extending its role beyond
classical purine metabolism.
Key finding 02
dA-to-dI editing may tune sensing
Deamination of deoxyadenosine residues appears to modulate immunogenic DNA signatures and shape innate
detection pathways.
Key finding 03
Implications for immune disease
This axis may reveal actionable mechanisms in autoimmune and autoinflammatory disorders and inform future
therapeutic strategies.
